System 06: HIV-1 RNA alternative splicing

Specification

We present a multi-site model describing the alternative use of the RNA splicing sites A3, A4, A5 and A7 in the human immunodeficiency virus HIV-1. Our goal is to integrate experimental data obtained on individual splicing sites into a global model of HIV-1 RNA alternative splicing. We give a qualitative validation of our model, and analyse the possible impact of variations of regulatory protein concentrations on virus multiplication.

References

@INPROCEEDINGS{cmsb04,
        AUTHOR             = {A. Bockmayr, A. Courtois, D. Eveillard and M. Vezain},
        BOOKTITLE          = {Computational Methods in Systems Biology, CMSB'04},
        PUBLISHER          = {Springer, LNCS},
        TITLE              = {Building and Analysing an Integrative Model of HIV-1 RNA Alternative Splicing},
        YEAR               = {2004}
}

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